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Journal article

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.

Abstract:

Atopic dermatitis is a common pruritic skin disease in which barrier dysfunction and cutaneous inflammation play a role in pathogenesis. Mechanisms underlying the associated inflammation are not fully understood, and while CD1a-expressing Langerhans cells are known to be enriched within lesions, their role in clinical disease pathogenesis has not been studied. Here we observed that house dust mite (HDM) generates neolipid antigens for presentation by CD1a to T cells in the blood and skin lesi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/scitranslmed.aad6833

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Funding agency for:
Jarrett, R
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science translational medicine Journal website
Volume:
8
Issue:
325
Article number:
325ra18
Publication date:
2016-02-10
Acceptance date:
2015-12-29
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Source identifiers:
605923
Language:
English
Pubs id:
pubs:605923
UUID:
uuid:17869a7a-d9ca-4aae-bf31-00cfe41e24fe
Local pid:
pubs:605923
Deposit date:
2016-03-30

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