Journal article
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
- Abstract:
-
Autoantibodies against leucine-rich glioma inactivated 1 (LGI1) are found in patients with limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal antibodies (mAbs) against LGI1. We explore their sequences and binding characteristics, plus their pathogenic potential using transfected HEK293T cells, rodent neuronal preparations, and behavioural and electrophysiological assessments in vivo after mAb injections into the rodent hippocampus. In live cell-based assays, ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Brain Journal website
- Volume:
- 143
- Issue:
- 6
- Pages:
- 1731–1745
- Publication date:
- 2020-05-21
- Acceptance date:
- 2020-03-01
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- Pmid:
-
32437528
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1106414
- Local pid:
- pubs:1106414
- Deposit date:
- 2020-06-15
Terms of use
- Copyright holder:
- Ramberger et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
- Licence:
- CC Attribution (CC BY)
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