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Journal article

Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms

Abstract:

Autoantibodies against leucine-rich glioma inactivated 1 (LGI1) are found in patients with limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal antibodies (mAbs) against LGI1. We explore their sequences and binding characteristics, plus their pathogenic potential using transfected HEK293T cells, rodent neuronal preparations, and behavioural and electrophysiological assessments in vivo after mAb injections into the rodent hippocampus. In live cell-based assays, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awaa104

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
143
Issue:
6
Pages:
1731–1745
Publication date:
2020-05-21
Acceptance date:
2020-03-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
32437528
Language:
English
Keywords:
Pubs id:
1106414
Local pid:
pubs:1106414
Deposit date:
2020-06-15

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