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Association of vitamin D with risk of type 1 2 diabetes: a Mendelian 2 randomisation study in European and Chinese adults

Abstract:

Background: Observational studies have reported that higher plasma 25-hydroxy vitamin D (25[OH]D) concentrations are associated with lower risks of diabetes, but it is unclear if these associations are causal. The aim of this study was to test the relevance of 25(OH)D for type 2 diabetes using genetically-instrumented differences in plasma 25(OH)D concentrations.

Methods and findings: Data were available on four 25(OH)D single nucleotide polymorphisms (SNPs: n=82,464), pla...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.1002566

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
Expand authors...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
15
Issue:
5
Article number:
e1002566
Publication date:
2018-05-02
Acceptance date:
2018-04-06
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:835119
UUID:
uuid:17df73c8-c833-44ab-b063-7278b636e555
Local pid:
pubs:835119
Deposit date:
2018-04-11

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