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Thesis

Biophysical characterisation of the mechanisms regulating sarcoplasmic reticulum K+ channel gating

Abstract:

Intracellular Ca2+-release from the sarcoplasmic reticulum (SR) occurs through highly specialised Ca2+-release channels called ryanodine receptors (RyR) in a process known as excitation-contraction coupling (EC-coupling) in striated muscle.

The RyR is the main ion-channel mediating Ca2+-release from the SR but the SR also contains many other ion-channels and proteins, with many of unknown physiological role. For example, two SR K+ channels...

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Division:
MSD
Department:
Pharmacology
Role:
Author

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Role:
Supervisor
British Heart Foundation More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:17e51bc1-5b1f-4b52-8e46-98c888a91e00
Deposit date:
2016-10-11

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