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Metabolomics data for: Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

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These data support the paper "Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells". We have investigated the mechanism(s) by which chronic hyperglycaemia and diabetes lead to impaired β-cell metabolism and if this is linked to activation of mTORC1. We show that a glycolytic metabolite downstream of glucokinase and upstream of GAPDH mediates the effects of diabetes and chronic hyperglycemia on β-cell metabolism. This occurs, in part, through ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Researcher, Depositor, Creator
More by this author/creator
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Researcher, Creator
ORCID:
0000-0003-3097-9240
More by this author/creator
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Co-Investigator, Creator
ORCID:
0000-0003-4733-1205
More by this author/creator
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Principal Investigator (PI), Creator
ORCID:
0000-0002-6970-1767
Publisher:
University of Oxford
Publication date:
2022
DOI:
Language:
English
Keywords:
Subjects:
Deposit date:
2022-01-11

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