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The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

Abstract:

Lipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in prokaryotes. Haloarchaeal pleomorphic viruses (HRPVs) have a membrane envelope decorated with spikes that are presumed to be responsible for host attachment and membrane fusion. Here we determine atomic structures of the ectodomains of the 57-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-08728-7

Authors


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Institution:
University of Oxford
Division:
College Only
Department:
Somerville College
Oxford college:
Somerville College
Role:
Author
ORCID:
0000-0003-3506-6045
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0002-9353-0355
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0002-4480-5439
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0002-0030-7235
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Article number:
846
Publication date:
2019-02-19
Acceptance date:
2019-01-22
DOI:
EISSN:
2041-1723
Pmid:
30783086
Language:
English
Pubs id:
pubs:975920
UUID:
uuid:18e2acdd-000f-4366-8b0b-6a56452bc21a
Local pid:
pubs:975920
Source identifiers:
975920
Deposit date:
2019-03-11

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