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Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor

Abstract:

The monoclonal antibody hGR-2 F6 has been raised against the human glucagon receptor and shown to act as a competitive antagonist. As a first step in the structural characterization of the receptor, the crystal structure of the Fab fragment from this antibody is reported at 2.1 resolution. The hGR-2 F6 Fab crystallizes in the orthorhombic space group P21212, with unit-cell parameters a = 76.14, b = 133.74, c = 37.46 Å. A model generated by homology modelling was used as an aid in the chain-tr...

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Publisher copy:
10.1107/S090744490000233X

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Journal:
Acta Crystallographica Section D: Biological Crystallography
Volume:
56
Issue:
5
Pages:
573-580
Publication date:
2000-01-01
DOI:
ISSN:
0907-4449
Source identifiers:
317572
Language:
English
Pubs id:
pubs:317572
UUID:
uuid:1931a57d-7aa2-4621-8d8e-b5cb755c028c
Local pid:
pubs:317572
Deposit date:
2012-12-19

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