Journal article
Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor
- Abstract:
-
The monoclonal antibody hGR-2 F6 has been raised against the human glucagon receptor and shown to act as a competitive antagonist. As a first step in the structural characterization of the receptor, the crystal structure of the Fab fragment from this antibody is reported at 2.1 resolution. The hGR-2 F6 Fab crystallizes in the orthorhombic space group P21212, with unit-cell parameters a = 76.14, b = 133.74, c = 37.46 Å. A model generated by homology modelling was used as an aid in the chain-tr...
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- Publisher copy:
- 10.1107/S090744490000233X
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Bibliographic Details
- Journal:
- Acta Crystallographica Section D: Biological Crystallography
- Volume:
- 56
- Issue:
- 5
- Pages:
- 573-580
- Publication date:
- 2000-01-01
- DOI:
- ISSN:
-
0907-4449
- Source identifiers:
-
317572
Item Description
- Language:
- English
- Pubs id:
-
pubs:317572
- UUID:
-
uuid:1931a57d-7aa2-4621-8d8e-b5cb755c028c
- Local pid:
- pubs:317572
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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