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Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis

Abstract:

The microenvironment of a tumor may regulate the anti-tumor immune response. Intratumoral acidosis and hypoxia may suppress lymphocyte proliferation and migration, and this may have important implications in modern immunotherapy. The expression of PD-L1 by cancer cells and of PD-1 by tumor infiltrating lymphocytes (TILs) was assessed in tissue specimens from 98 operable NSCLC patients. Their prognostic role and their association with makers of glycolysis and anaerobic metabolism were assessed...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s12032-019-1299-4

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0003-1376-8409
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Tumor and Angiogenesis Research Group More from this funder
Publisher:
Springer Publisher's website
Journal:
Medical Oncology Journal website
Volume:
36
Article number:
76
Publication date:
2019-07-24
Acceptance date:
2019-07-17
DOI:
EISSN:
1559-131X
ISSN:
1357-0560
Pmid:
31342270
Language:
English
Keywords:
Pubs id:
1036741
Local pid:
pubs:1036741
Deposit date:
2020-08-20

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