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Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Abstract:

The CD4 binding site (CD4bs) of the HIV-1 envelope glycoprotein is susceptible to multiple lineages of broadly neutralizing antibodies (bnAbs) that are attractive to elicit with vaccines. The CH235 lineage (VH1-46) of CD4bs bnAbs is particularly attractive because the most mature members neutralize 90% of circulating strains, do not possess long HCDR3 regions, and do not contain insertions and deletions that may be difficult to induce. We used virus neutralization to measure the interaction o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1008026

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Role:
Author
ORCID:
0000-0002-6653-6655
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Role:
Author
ORCID:
0000-0003-2065-3802
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Role:
Author
ORCID:
0000-0001-8676-2345
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Role:
Author
ORCID:
0000-0001-9192-0440
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
15
Issue:
9
Article number:
e1008026
Publication date:
2019-09-17
Acceptance date:
2019-08-12
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
31527908
Language:
English
Keywords:
Pubs id:
1054241
Local pid:
pubs:1054241
Deposit date:
2020-01-30

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