Journal article
Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies
- Abstract:
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The CD4 binding site (CD4bs) of the HIV-1 envelope glycoprotein is susceptible to multiple lineages of broadly neutralizing antibodies (bnAbs) that are attractive to elicit with vaccines. The CH235 lineage (VH1-46) of CD4bs bnAbs is particularly attractive because the most mature members neutralize 90% of circulating strains, do not possess long HCDR3 regions, and do not contain insertions and deletions that may be difficult to induce. We used virus neutralization to measure the interaction o...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 172.8KB)
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(Version of record, 3.4MB)
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- Publisher copy:
- 10.1371/journal.ppat.1008026
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Authors
Funding
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Pathogens Journal website
- Volume:
- 15
- Issue:
- 9
- Article number:
- e1008026
- Publication date:
- 2019-09-17
- Acceptance date:
- 2019-08-12
- DOI:
- EISSN:
-
1553-7374
- ISSN:
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1553-7366
- Pmid:
-
31527908
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1054241
- Local pid:
- pubs:1054241
- Deposit date:
- 2020-01-30
Terms of use
- Copyright holder:
- Public Domain
- Copyright date:
- 2019
- Rights statement:
- This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Notes:
- A correction to this article is available at: https://doi.org/10.1371/journal.ppat.1008200
- Licence:
- Other
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