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Thesis

The role of Adaptor Protein 3 in cytotoxic T lymphocytes

Abstract:

Cytotoxic T lymphocytes (CTL) kill virally infected and tumourigenic cells via the regulated secretion of specialised secretory lysosomes. These secretory lysosomes contain cytolytic effector molecules, such as perforin and granzymes, which are able to induce apoptosis in target cells. Secretion occurs at the contact point between the CTL and its target, in a highly structured region termed the immunological synapse (IS). Upon formation of the IS, CTL undergo polarisation of their microtubule...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Prof Gillian Griffiths
Oxford college:
St John's College
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
More from this funder
Funding agency for:
Wenham, M
Publication date:
2009
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:1a5c1fd6-c8cc-454f-81a5-b9a5a18c1540
Local pid:
ora:3230
Deposit date:
2010-01-18

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