Journal article
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy
- Abstract:
-
Potentiating radiotherapy and chemotherapy by inhibiting DNA damage repair is proposed as a therapeutic strategy to improve outcomes for patients with solid tumors. However, this approach risks enhancing normal tissue toxicity as much as tumor toxicity, thereby limiting its translational impact. Using NU5455, a newly identified highly selective oral inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity, we found that it was indeed possible to preferentially augment t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of clinical investigation Journal website
- Volume:
- 130
- Issue:
- 1
- Pages:
- 258-271
- Publication date:
- 2020-01-01
- Acceptance date:
- 2019-09-25
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- Pmid:
-
31581151
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1074835
- Local pid:
- pubs:1074835
- Deposit date:
- 2020-03-10
Terms of use
- Copyright holder:
- Willoughby et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020, Willoughby et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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