Journal article
25-hydroxy- and 1α,25-dihydroxycholecalciferol have greater potencies than 25-hydroxy- and 1α,25-dihydroxyergocalciferol in modulating cultured human and mouse osteoblast activities
- Abstract:
-
Despite differences in the phamacokinetics of 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2) in man, the effects of these and their 1α-hydroxylated forms (1,25(OH)2D3 and 1,25(OH)2D2) on cellular activity of vitamin D-responsive cells have hardly been compared. We studied differences in the effects of these metabolites on cell number, gene transcription, protein expression and mineralisation of cultured human bone marrow-derived stromal cells (hBMSC) and rapidly ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
National Institute for Health Research
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS One Journal website
- Volume:
- 11
- Issue:
- 11
- Pages:
- e0165462
- Publication date:
- 2016-11-28
- Acceptance date:
- 2016-10-12
- DOI:
- EISSN:
-
1932-6203
- ISSN:
-
1932-6203
- Pmid:
-
27893751
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:663831
- UUID:
-
uuid:1a909fce-88f2-41cd-a9c9-4c1ebd86ea38
- Local pid:
- pubs:663831
- Source identifiers:
-
663831
- Deposit date:
- 2018-12-19
Terms of use
- Copyright holder:
- Zarei et al
- Copyright date:
- 2016
- Notes:
- © 2016 Zarei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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