Journal article icon

Journal article

Enhancers predominantly regulate gene expression during differentiation via transcription initiation

Abstract:

Gene transcription occurs via a cycle of linked events, including initiation, promoter-proximal pausing, and elongation of RNA polymerase II (Pol II). A key question is how transcriptional enhancers influence these events to control gene expression. Here, we present an approach that evaluates the level and change in promoter-proximal transcription (initiation and pausing) in the context of differential gene expression, genome-wide. This combinatorial approach shows that in primary cells, cont...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.molcel.2021.01.002

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0003-1076-5595
Expand authors...
Publisher:
Cell Press Publisher's website
Journal:
Molecular Cell Journal website
Volume:
81
Issue:
5
Pages:
983-997
Publication date:
2021-02-03
Acceptance date:
2021-01-02
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pmid:
33539786
Language:
English
Keywords:
Pubs id:
1160108
Local pid:
pubs:1160108
Deposit date:
2021-02-12

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP