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Thesis

Understanding regulation of zeta-globin transcription as the first step towards embryonic globin induction in patients with severe alpha-thalassemia

Alternative title:
Regulation of zeta-globin transcription
Abstract:

It is estimated by the World Health Organization that 250,000 individuals with severe hemoglobinopathies are born each year. A significant proportion of these suffer from @alpha;-thalassemia, which is one of the most common human monogenic disorders known with a carrier rate of >1% among all tropical and subtropical populations that have been studied. A common cause of alpha-thalassemia is an intra chromosomal deletion, termed the Southeast Asian (SEA) deletion, which removes both a...

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Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Department:
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:1afb5841-042c-4e54-9012-bbc6783649b1
Deposit date:
2016-06-20

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