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Placental capillary pericytes release more exosomes and immunomodulatory and growth factors in response to hypoxia

Abstract:

Excess hypoxia can lead to developmental abnormalities and antenatal deficits such as fetal intrauterine growth restriction and preeclampsia. Capillary pericytes are multifunctional cells wrapped around the vascular endothelium that play essential roles in vascular development and blood flood regulation. In vivo, brain pericytes respond to hypoxia by irreversibly constricting capillaries and thus causing cell death in rigor. To date, placental capillary pericytes (PLVP) have not been fully ch...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
International Federation of Placenta Associations Meeting (IFPA 2018) Journal website
Volume:
69
Issue:
6
Pages:
E75-E76
Host title:
Placenta
Publication date:
2018-09-10
DOI:
EISSN:
1532-3102
ISSN:
0143-4004
Source identifiers:
921713
Pubs id:
pubs:921713
UUID:
uuid:1b01131f-37c2-401b-bb0c-7b266f7c688b
Local pid:
pubs:921713
Deposit date:
2018-10-02

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