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The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress

Abstract:

Oxidative stress is a pathological feature of many neurological disorders, therefore utilizing proteins that are protective against such cellular insults is a potentially valuable therapeutic approach. Oxidation resistance 1 (OXR1) has been shown previously to be critical for oxidative stress resistance in neuronal cells; deletion of this gene causes neurodegeneration in mice, yet conversely, over-expression of OXR1 is protective in cellular and mouse models of amyotrophic lateral sclerosis (...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.M115.685222

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Medical Research Council More from this funder
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Pages:
jbc.M115.685222-jbc.M115.685222
Publication date:
2015-12-14
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
588135
Language:
English
Keywords:
Pubs id:
pubs:588135
UUID:
uuid:1b3471d6-259c-495c-be4e-517573718bfc
Local pid:
pubs:588135
Deposit date:
2016-01-27

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