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Functional characterization of the NF-kappa B transcription factor gene REL2 from Anopheles gambiae

Abstract:

The REL2 gene plays an important role in innate immunity against both Gram (+) and Gram (-) bacteria and malaria parasites in Anopheles gambiae, the main vector of malaria in Africa. Through alternative splicing, REL2 produces two protein products, REL2F (with a Rel-homology domain as well as an inhibitory ankyrin repeat region) and REL2S (without the ankyrin repeats). In the immune-competent cell line Sua1B from An. gambiae, REL2 has been shown to be a key regulator for cecropin A (or CEC1)....

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Publication status:
Published

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Journal:
INSECT SCIENCE
Volume:
14
Issue:
3
Pages:
175-184
Publication date:
2007-06-01
DOI:
EISSN:
1744-7917
ISSN:
1672-9609
Source identifiers:
101957
Language:
English
Keywords:
Pubs id:
pubs:101957
UUID:
uuid:1b697169-0df0-4f4e-a67b-b13333e73291
Local pid:
pubs:101957
Deposit date:
2013-11-16

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