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ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants

Abstract:

Background: Our laboratory identified ADGRL4/ELTD1, an orphan GPCR belonging to the adhesion GPCR (aGPCR) family, as a novel regulator of angiogenesis and a potential anti-cancer therapeutic target. Little is known about how ADGRL4/ELTD1 (and aGPCRs in general) function, a problem compounded by a lack of known ligands or means of activation. With this in mind, we turned to computational evolutionary biology with the aim of better understanding ADGRL4/ELTD1.
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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12862-019-1445-9

Authors


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Institution:
University of Oxford
Department:
Balliol College
Role:
Author
ORCID:
0000-0003-3189-6658
More by this author
Institution:
University of Oxford
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0002-3197-273X
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0003-1376-8409
Publisher:
BioMed Central Publisher's website
Journal:
BMC Evolutionary Biology Journal website
Volume:
19
Issue:
2019
Article number:
143
Publication date:
2019-07-12
Acceptance date:
2019-05-27
DOI:
EISSN:
1471-2148
Pmid:
31299890
Source identifiers:
1036742
Language:
English
Keywords:
Pubs id:
pubs:1036742
UUID:
uuid:1baf1174-b578-453c-ad52-78ef318c4207
Local pid:
pubs:1036742
Deposit date:
2019-08-14

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