Statistical HLA type imputation from large and heterogeneous datasets
An individual's Human Leukocyte Antigen (HLA) type is an essential immunogenetic parameter, influencing susceptibility to a variety of autoimmune and infectious diseases, to certain types of cancer and the likelihood of adverse drug reactions.
I present and evaluate two models for the accurate statistical determination of HLA types for single-population and multi-population studies, based on SNP genotypes. Importantly, SNP genotypes are already available for many studies, so that the...Expand abstract
- Publication date:
- Type of award:
- Level of award:
- Awarding institution:
- Oxford University, UK
- Local pid:
- Copyright holder:
- Alexander Dilthey
- Copyright date:
- Please note that 2 figures have been removed from this version of the thesis for copyright reasons.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record