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Thesis

Statistical HLA type imputation from large and heterogeneous datasets

Abstract:

An individual's Human Leukocyte Antigen (HLA) type is an essential immunogenetic parameter, influencing susceptibility to a variety of autoimmune and infectious diseases, to certain types of cancer and the likelihood of adverse drug reactions.

I present and evaluate two models for the accurate statistical determination of HLA types for single-population and multi-population studies, based on SNP genotypes. Importantly, SNP genotypes are already available for many studies, so that the...

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Research group:
Professor Gil McVean
Oxford college:
St Peter's College
Role:
Author

Contributors

Division:
MPLS
Department:
Statistics
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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