Thesis
Statistical HLA type imputation from large and heterogeneous datasets
- Abstract:
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An individual's Human Leukocyte Antigen (HLA) type is an essential immunogenetic parameter, influencing susceptibility to a variety of autoimmune and infectious diseases, to certain types of cancer and the likelihood of adverse drug reactions.
I present and evaluate two models for the accurate statistical determination of HLA types for single-population and multi-population studies, based on SNP genotypes. Importantly, SNP genotypes are already available for many studies, so that the...
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Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
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uuid:1bca18bf-b9d5-4777-b58e-a0dca4c9dbea
- Local pid:
- ora:6485
Item Description
- Language:
- English
- Keywords:
- Subjects:
Terms of use
- Copyright holder:
- Alexander Dilthey
- Copyright date:
- 2012
- Notes:
- Please note that 2 figures have been removed from this version of the thesis for copyright reasons.
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