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Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: observational and mendelian randomization analyses

Abstract:
Background
Brain iron deposition has been linked to several neurodegenerative conditions and reported in alcohol dependence. Whether iron accumulation occurs in moderate drinkers is unknown. Our objectives were to investigate evidence in support of causal relationships between alcohol consumption and brain iron levels and to examine whether higher brain iron represents a potential pathway to alcohol-related cognitive deficits.
Methods and findings
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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.1004039

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
ORCID:
0000-0002-8408-0372
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0002-5190-7038
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
19
Issue:
7
Article number:
e1004039
Publication date:
2022-07-14
Acceptance date:
2022-06-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Language:
English
Keywords:
Pubs id:
1261203
Local pid:
pubs:1261203
Deposit date:
2022-06-07

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