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Journal article

Mechanics of mouse blastocyst hatching revealed by a hydrogel-based microdeformation assay

Abstract:

Mammalian embryos are surrounded by an acellular shell, the zona pellucida. Hatching out of the zona is crucial for implantation and continued development of the embryo. Clinically, problems in hatching can contribute to failure in assisted reproductive intervention. Although hatching is fundamentally a mechanical process, due to limitations in methodology most studies focus on its biochemical properties. To understand the role of mechanical forces in hatching, we developed a hydrogel deforma...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1719930115

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0003-3623-600X
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Funding agency for:
Leonavicius, K
Grant:
203141/Z/16/Z
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Funding agency for:
Leonavicius, K
Grant:
203141/Z/16/Z
More from this funder
Funding agency for:
Leonavicius, K
Grant:
203141/Z/16/Z
More from this funder
Funding agency for:
Srinivas, S
Grant:
Senior Investigator Award (103788/Z/14/Z
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
41
Pages:
10375-10380
Publication date:
2018-09-19
Acceptance date:
2018-08-15
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
30232257
Source identifiers:
920894
Language:
English
Keywords:
Pubs id:
pubs:920894
UUID:
uuid:1c1f844a-09ce-49b0-be61-0838b3ff03ce
Local pid:
pubs:920894
Deposit date:
2018-10-25

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