Journal article
Covalent strategies for targeting messenger and non-coding RNAs: an updated review on siRNA, miRNA and antimiR conjugates
- Abstract:
-
Oligonucleotide-based therapy has become an alternative to classical approaches in the search of novel therapeutics involving gene-related diseases. Several mechanisms have been described in which demonstrate the pivotal role of oligonucleotide for modulating gene expression. Antisense oligonucleotides (ASOs) and more recently siRNAs and miRNAs have made important contributions either in reducing aberrant protein levels by sequence-specific targeting messenger RNAs (mRNAs) or restoring the an...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.8MB)
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- Publisher copy:
- 10.3390/genes9020074
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Authors
Funding
+ Ministerio de Economía, Industria y Competitividad
More from this funder
Grant:
CTQ2014-52588-R, CTQ2017-84415-R, RTC-2014-2038-1
Bibliographic Details
- Publisher:
- MDPI Publisher's website
- Journal:
- Genes Journal website
- Volume:
- 9
- Issue:
- 2
- Article number:
- 74
- Publication date:
- 2018-02-06
- Acceptance date:
- 2018-01-26
- DOI:
- ISSN:
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2073-4425
- Pmid:
-
29415514
- Source identifiers:
-
825410
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:825410
- UUID:
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uuid:1c8801fe-aee5-4f47-8c32-ca8db50fbd1c
- Local pid:
- pubs:825410
- Deposit date:
- 2018-06-07
Terms of use
- Copyright holder:
- Grijalvo et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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