Journal article
Kinetics of abacavir-induced remodelling of the major histocompatibility complex class I peptide repertoire
- Abstract:
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Abacavir hypersensitivity syndrome can occur in individuals expressing the HLA-B*57:01 major histocompatibility complex class I allotype when utilising the drug abacavir as a part of their anti-retroviral regimen. The drug is known to bind within the HLA-B*57:01 antigen binding cleft, leading to the selection of novel self-peptide ligands, thus provoking life-threatening immune responses. However, the sub-cellular location of abacavir binding and the mechanics of altered peptide selection are...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 8.0MB)
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- Publisher copy:
- 10.3389/fimmu.2021.672737
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Authors
Funding
Biotechnology and Biological Sciences Research Council
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Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Immunology Journal website
- Volume:
- 12
- Article number:
- 672737
- Publication date:
- 2021-05-19
- Acceptance date:
- 2021-04-26
- DOI:
- EISSN:
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1664-3224
- Pmid:
-
34093574
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1181940
- Local pid:
- pubs:1181940
- Deposit date:
- 2021-06-27
Terms of use
- Copyright holder:
- Illing et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright © 2021 Illing, van Hateren, Darley, Croft, Mifsud, King, Kostenko, Bharadwaj, McCluskey, Elliott and Purcell. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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