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Thesis

Understanding immunity differences induced by whole cell and acellular pertussis vaccines in a paediatric population

Alternative title:
Immunity differences between pertussis vaccines
Abstract:

Bordetella pertussis causes whooping cough, a life-threatening disease in infants. Both whole cell (wP) and acellular (aP) vaccines are used for infant immunisation with aP providing less robust long-term population protection. To further understand differences between wP and aP, this thesis aims: to characterise the immune response to an aP-booster in a UK cohort by age and priming backgrounds (wP/aP) using a broad variety of assays of humoral immunity; to investigate effect of HLA-DRB1-2...

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Sub department:
Paediatrics
Research group:
Oxford Vaccine Group
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0002-9716-7848

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Research group:
Oxford Vaccine Group
Role:
Contributor
ORCID:
0000-0001-7361-719X
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Sub department:
Paediatrics
Research group:
Oxford Vaccine Group
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Sub department:
Paediatrics
Research group:
Oxford Vaccine Group
Role:
Supervisor
ORCID:
0000-0003-1701-1390
Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
ORCID:
0000-0002-4502-2209
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Sub department:
Paediatrics
Research group:
Oxford Vaccine Group
Role:
Supervisor
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Funding agency for:
Martins Valente Pinto, AM
Grant:
16/17_MSD_1048879
16/17_MSD_1048879
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Programme:
The Periscope (PERtussIS COrrelate of Protection Europe
Funding agency for:
Pollard, A
Grant:
115910
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Programme:
EUCLIDS study
Funding agency for:
Pollard, A
Grant:
279185
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Programme:
Sched 3 study
Funding agency for:
Snape, M
Grant:
039/0031
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Funding agency for:
Martins Valente Pinto, AM
Grant:
1297 Apr-18
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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