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IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system

Abstract:

Background

Viral encephalitis is a common cause of lethal infections in humans, and several different viruses are documented to be responsible. Rocio virus is a flavivirus that causes a severe lethal encephalitis syndrome in humans and also mice, providing an interesting model to study the CNS compartmentalized immune response. Interleukin 33 (IL-33), a member of the IL-1 family, is an immunomodulatory cytokine that is highly expressed in the CNS. However, the role of IL-33 on vi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12974-016-0628-1

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
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Grant:
HEALTH-F4-2011-281608 (TIMER
Publisher:
BioMed Central Publisher's website
Journal:
Journal of Neuroinflammation Journal website
Volume:
13
Issue:
1
Pages:
159
Publication date:
2016-06-22
Acceptance date:
2016-08-15
DOI:
EISSN:
1742-2094
Pmid:
27334012
Source identifiers:
687572

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