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Thesis

Investigating DNA double-strand break repair in Dictyostelium discoideum

Abstract:

DNA double-strand breaks (DSBs) are toxic lesions that can be repaired by numerous mechanistically distinct pathways. However, regulation of DSB repair pathway utilisation is also essential for maintaining genomic integrity, and eukaryotes have evolved several mechanisms to achieve this. This includes post-translational modifications of DSB repair proteins to modulate their activity at DNA DSB ends. One example of a post-translational modification with a role in DNA repair is Poly-ADP ri...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Lakin
Oxford college:
Merton College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:1d3743ef-7271-4dc4-816e-b9f8872c5379
Deposit date:
2016-11-15

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