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Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses.

Abstract:

CD161 is a C-type lectin-like receptor expressed on human natural killer (NK) cells and subsets of T cells. CD161 has been described as an inhibitory receptor that regulates NK cell-mediated cytotoxicity and IFN-γ production. Its role on T cells has remained unclear. Studies have shown that triggering of CD161 enhances NK T cell proliferation and T cell-IFN-γ production while inhibiting TNF-α production by CD8(+) T cells. Lectin-like transcript 1 (LLT1), the ligand of CD161, was found to be e...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m111.285312

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Journal:
Journal of biological chemistry
Volume:
286
Issue:
44
Pages:
37964-37975
Publication date:
2011-11-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
220453

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