Journal article icon

Journal article

Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.

Abstract:

Generation of the HLA-A0201 (A2) influenza Matrix 58-66 epitope contained within the full-length Matrix protein is impaired in cells lacking the proteasome subunits low molecular protein 2 (LMP2) and LMP7. This Ag presentation block can be relieved by transfecting the wild-type LMP7 cDNA into LMP7-deficient cells. A mutated form of LMP7, lacking the two threonines at the catalytic active site, was equally capable of relieving the block in presentation of the influenza Matrix A2 epitope. These...

Expand abstract
Publication status:
Published

Actions


Authors


Expand authors...
Journal:
Journal of Immunology
Volume:
163
Issue:
11
Pages:
6045-6052
Publication date:
1999-12-01
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
21691
Language:
English
Keywords:
Pubs id:
pubs:21691
UUID:
uuid:1d9dc996-f062-4a29-a656-3b08eed1212b
Local pid:
pubs:21691
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP