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Thesis

Studies of piRNA synthesis

Abstract:

RNA silencing is a form of post-transcriptional gene regulation, in which a small RNA guides a member of the Argonaute protein family in an effector complex to repress target gene expression. piRNAs, found in germ cells, are the most recently discovered major subset of small RNAs. A key known function of piRNA is to repress the transposable elements in the germline and maintain the germline genome integrity. The defining features of the piRNAs are 1) they are ubiquitously methylated at the 3’...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Lincoln College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
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Funding agency for:
Wang, M
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:1e134b7b-4e9d-4d0e-bfd8-e4696f960ad6
Local pid:
ora:8534
Deposit date:
2014-06-06

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