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Ecological effects on underdominance threshold drives for vector control

Abstract:

Underdominance gene drives are frequency-dependent drives that aim to spread a desired homozygote genotype within a population. When the desired homozygote is released above a threshold frequency, heterozygote fitness disadvantage acts to drive the desired trait to fixation. Underdominance drives have been proposed as a way to control vector-borne disease through population suppression and replacement in a spatially contained and reversible way—benefits that directly address potential safety ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jtbi.2018.07.024

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
RDM; Clinical Laboratory Sciences
Role:
Author
More by this author
Division:
Medical Sciences
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Maths, Physical & Life Sciences
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
St Peter's College
Role:
Author
Defense Advanced Research Projects Agency More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Theoretical Biology Journal website
Volume:
456
Pages:
1-15
Publication date:
2018-07-21
Acceptance date:
2018-07-19
DOI:
ISSN:
0022-5193
Source identifiers:
885494
Keywords:
Pubs id:
pubs:885494
UUID:
uuid:1e2e0d0f-00ac-4f70-9992-e0dbeabe8af9
Local pid:
pubs:885494
Deposit date:
2018-07-19

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