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Hypoxia-Inducible Factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2

Abstract:

Osteogenic-angiogenic coupling is promoted by the Hypoxia-Inducible Factor 1-alpha (HIF-1α) transcription factor, provoking interest in HIF activation as a therapeutic strategy to improve osteoblast mineralisation and treat pathological osteolysis. However, HIF also enhances the bone resorbing activity of mature osteoclasts. It is therefore essential to determine the full effect(s) of HIF on both the formation and bone-resorbing function of osteoclasts in order to understand how they might re...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/path.4906

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Funding agency for:
Hulley, P
Grant:
12/206/30
More from this funder
Funding agency for:
Hulley, P
Grant:
12/206/30
More from this funder
Funding agency for:
Hulley, P
Grant:
12/206/30
More from this funder
Funding agency for:
Hulley, P
Grant:
12/206/30
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Publisher:
Wiley Publisher's website
Journal:
Journal of Pathology Journal website
Volume:
242
Issue:
3
Pages:
322–333
Publication date:
2017-04-18
Acceptance date:
2017-04-03
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Language:
English
Keywords:
Pubs id:
pubs:690943
UUID:
uuid:1e3f68ec-a1be-49d2-aa29-605fc84a489d
Local pid:
pubs:690943
Deposit date:
2017-05-02

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