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Journal article

Heart regeneration and repair after myocardial infarction: Translational opportunities for novel therapeutics

Abstract:

Current therapies for heart failure after myocardial infarction are limited and non-curative. Although regenerative approaches are receiving significant attention, clinical efforts that involve transplantation of presumed stem and progenitor cells have largely failed to deliver. Recent studies of endogenous heart regeneration in model organisms, such as zebrafish and neonatal mice, are yielding mechanistic insights into the roles of cardiomyocyte proliferation, resident stem cell niches, neov...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nrd.2017.106

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Oxford college:
Balliol College
Role:
Author
ORCID:
0000-0002-8046-1688
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0002-9862-7332
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Funding agency for:
Cahill, T
Grant:
106334/Z/14/Z
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Funding agency for:
Riley, P
Grant:
RG/13/9/303269
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Reviews Drug Discovery Journal website
Volume:
16
Issue:
10
Pages:
699-717
Publication date:
2017-07-21
Acceptance date:
2017-05-11
DOI:
EISSN:
1474-1784
ISSN:
1474-1776
Pmid:
28729726
Source identifiers:
709417
Language:
English
Keywords:
Pubs id:
pubs:709417
UUID:
uuid:1e4a939b-5ae8-4285-8a3c-2c6555135862
Local pid:
pubs:709417
Deposit date:
2018-10-10

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