Journal article
BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells
- Abstract:
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Bromodomain-containing protein 4 (BRD4) is a member of the bromo- and extraterminal (BET) domain-containing family of epigenetic readers which is under intensive investigation as a target for anti-tumor therapy. BRD4 plays a central role in promoting the expression of select subsets of genes including many driven by oncogenic transcription factors and signaling pathways. However, the role of BRD4 and the effects of BET inhibitors in non-transformed cells remain mostly unclear. We demonstrate ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 6.7MB)
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- Publisher copy:
- 10.1093/nar/gkw1276
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Authors
Funding
German Academic Exchange Service
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Erasmus Mundus External Cooperation Window
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Gottingen Graduate School for Neurosciences, Biophysics and Molecular Biosciences
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Cancer Prevention Research Institute of Texas
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 45
- Issue:
- 6
- Pages:
- 3130-3145
- Publication date:
- 2016-12-15
- Acceptance date:
- 2016-12-09
- DOI:
- EISSN:
-
1362-4962
- ISSN:
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0305-1048
- Pmid:
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27980063
- Source identifiers:
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666490
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:666490
- UUID:
-
uuid:1f5ce371-7643-4cd2-a466-5d39bac395de
- Local pid:
- pubs:666490
- Deposit date:
- 2018-07-13
Terms of use
- Copyright holder:
- Knapp et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
- Licence:
- CC Attribution (CC BY)
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