Journal article
How gene-drive endonucleases can be used to combat pests and disease vectors
- Abstract:
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Gene-drive endonucleases (GDEs) are genes that can spread through a population through a non-Mendelian mechanism. In a heterozygote they cause a double-strand break in the homologous chromosome opposite to where they are inserted and when the break is repaired using the homologue as a template the GDE heterozygote is converted to a homozygote. Several classes of endonucleases can be engineered to spread in this way, with CRISPR-Cas9 based systems being particularly flexible. There is great in...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1186/s12915-017-0420-4
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Authors
Funding
Bill & Melinda Gates Foundation
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Biology Journal website
- Volume:
- 15
- Issue:
- 81
- Pages:
- 1-12
- Publication date:
- 2017-09-11
- Acceptance date:
- 2017-06-29
- DOI:
- ISSN:
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1741-7007
- Source identifiers:
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702533
Item Description
- Keywords:
- Pubs id:
-
pubs:702533
- UUID:
-
uuid:1f803b44-da7a-4240-ab24-fe2e04993e03
- Local pid:
- pubs:702533
- Deposit date:
- 2017-06-30
Terms of use
- Copyright holder:
- © Godfray, North & Burt 2017
- Copyright date:
- 2017
- Notes:
- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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