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How gene-drive endonucleases can be used to combat pests and disease vectors

Abstract:

Gene-drive endonucleases (GDEs) are genes that can spread through a population through a non-Mendelian mechanism. In a heterozygote they cause a double-strand break in the homologous chromosome opposite to where they are inserted and when the break is repaired using the homologue as a template the GDE heterozygote is converted to a homozygote. Several classes of endonucleases can be engineered to spread in this way, with CRISPR-Cas9 based systems being particularly flexible. There is great in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12915-017-0420-4

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Institution:
University of Oxford
Oxford college:
Jesus College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Bill & Melinda Gates Foundation More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Biology Journal website
Volume:
15
Issue:
81
Pages:
1-12
Publication date:
2017-09-11
Acceptance date:
2017-06-29
DOI:
ISSN:
1741-7007
Source identifiers:
702533
Keywords:
Pubs id:
pubs:702533
UUID:
uuid:1f803b44-da7a-4240-ab24-fe2e04993e03
Local pid:
pubs:702533
Deposit date:
2017-06-30

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