Working paper icon

Working paper

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Abstract:

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and also identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identify 43 genomic loci associated with either number of children ever born (NEB) or childlessness. These loci span diverse aspects of reproductive biology across the life course, including puberty timing, age at first birth, sex hormone regulation and age at menopause. Missense...

Expand abstract
Publication status:
Submitted
Peer review status:
Not peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1101/2020.05.19.104455

Authors


More by this author
Institution:
University of Pennsylvania
Role:
Author
More by this author
Institution:
University of Cambridge
Role:
Author
ORCID:
0000-0003-3789-7651
More by this author
Institution:
University of Oxford
Division:
SSD
Department:
Sociology
Role:
Author
ORCID:
0000-0002-4362-4652
More by this author
Institution:
University of Oxford
Division:
SSD
Department:
Sociology
Oxford college:
Nuffield College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
SSD
Department:
Sociology
Sub department:
Sociology
Research group:
Leverhulme Centre for Demographic Science
Oxford college:
Nuffield College
Role:
Author
ORCID:
0000-0001-5361-2498
Expand authors...
European Research Council More from this funder
Publisher:
bioRxiv Publisher's website
Publication date:
2020-05-22
DOI:
Pubs id:
1107167
Local pid:
pubs:1107167
Deposit date:
2020-05-28

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP