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Mass spectrometry: from plasma proteins to mitochondrial membranes

Abstract:

In this Inaugural Article, I trace some key steps that have enabled the development of mass spectrometry for the study of intact protein complexes from a variety of cellular environments. Beginning with the preservation of the first soluble complexes from plasma, I describe our early experiments that capitalize on the heterogeneity of subunit composition during assembly and exchange reactions. During these investigations, we observed many assemblies and intermediates with different subunit st...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1820450116

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0001-7829-5505
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
8
Pages:
2814-2820
Publication date:
2019-02-04
Acceptance date:
2018-12-26
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
30718422
Source identifiers:
969518
Language:
English
Keywords:
Pubs id:
pubs:969518
UUID:
uuid:1fc40125-fa52-4f51-aac9-614bb232a585
Local pid:
pubs:969518
Deposit date:
2019-06-28

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