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Journal article

Crosstalk between regulatory T cells and tumor-associated dendritic cells negates anti-tumor immunity in pancreatic cancer

Abstract:

Regulatory T (Treg) cell infiltration constitutes a prominent feature of pancreatic ductal adenocarcinoma (PDA). However, the immunomodulatory function of Treg cells in PDA is poorly understood. Here, we demonstrate that Treg cell ablation is sufficient to evoke effective anti-tumor immune response in early and advanced pancreatic tumorigenesis in mice. This response is dependent on interferon-g (IFN-g)-producing cytotoxic CD8+ T cells. We show that Treg cells engage in extended interactions ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2017.06.062

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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American Association for Cancer Research More from this funder
Laura and Isaac Perlmutter Cancer Center More from this funder
Lustgarten Foundation PancreaticCancer Convergence DreamTeamg More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
20
Issue:
3
Pages:
558-571
Publication date:
2017-07-01
Acceptance date:
2017-06-21
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pmid:
28723561
Language:
English
Keywords:
Pubs id:
pubs:709644
UUID:
uuid:203ef3af-8bd9-4ac9-b8dd-341e6a44d7f7
Local pid:
pubs:709644
Deposit date:
2017-08-16

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