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Cutaneous HPV5 E6 causes increased expression of Osteoprotegerin and Interleukin 6 which contribute to evasion of UV-induced apoptosis.

Abstract:

Human papillomaviruses (HPVs) are small DNA viruses, which specifically infect keratinocytes at different body sites. The association between cutaneous squamous cell carcinoma (SCC) formation, ultraviolet (UV) irradiation and infection with a high-risk subset of cutaneous HPVs has been postulated although the underlying molecular mechanisms by which HPV may play a role in SCC development are not yet fully elucidated. Expression of the viral E6 oncoprotein has been shown to interfere with DNA ...

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Publication status:
Published

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Publisher copy:
10.1093/carcin/bgq200

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Carcinogenesis
Volume:
31
Issue:
12
Pages:
2155-2164
Publication date:
2010-12-01
DOI:
EISSN:
1460-2180
ISSN:
0143-3334
Source identifiers:
179069
Language:
English
Keywords:
Pubs id:
pubs:179069
UUID:
uuid:206ec849-d386-42e3-ba35-ac2910f863e3
Local pid:
pubs:179069
Deposit date:
2012-12-19

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