Journal article
Persistent malignant stem cells in del(5q) myelodysplasia in remission.
- Abstract:
-
BACKGROUND: The in vivo clinical significance of malignant stem cells remains unclear. METHODS: Patients who have the 5q deletion (del[5q]) myelodysplastic syndrome (interstitial deletions involving the long arm of chromosome 5) have complete clinical and cytogenetic remissions in response to lenalidomide treatment, but they often have relapse. To determine whether the persistence of rare but distinct malignant stem cells accounts for such relapses, we examined bone marrow specimens obtained ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1056/nejmoa0912228
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Bibliographic Details
- Journal:
- New England journal of medicine
- Volume:
- 363
- Issue:
- 11
- Pages:
- 1025-1037
- Publication date:
- 2010-09-01
- DOI:
- EISSN:
-
1533-4406
- ISSN:
-
0028-4793
- Source identifiers:
-
71173
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:71173
- UUID:
-
uuid:20a5cd50-8995-4328-884e-5c836a2563da
- Local pid:
- pubs:71173
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2010
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