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Journal article

Persistent malignant stem cells in del(5q) myelodysplasia in remission.

Abstract:

BACKGROUND: The in vivo clinical significance of malignant stem cells remains unclear. METHODS: Patients who have the 5q deletion (del[5q]) myelodysplastic syndrome (interstitial deletions involving the long arm of chromosome 5) have complete clinical and cytogenetic remissions in response to lenalidomide treatment, but they often have relapse. To determine whether the persistence of rare but distinct malignant stem cells accounts for such relapses, we examined bone marrow specimens obtained ...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa0912228

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Journal:
New England journal of medicine
Volume:
363
Issue:
11
Pages:
1025-1037
Publication date:
2010-09-01
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Source identifiers:
71173

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