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Journal article

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

Alternative title:
Recurrent activating ACVR1/ALK2 mutations in diffuse intrinsic pontine glioma
Abstract:

Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of the ventral pons that, due to their location within the brain, are unsuitable for surgical resection and consequently have a universally dismal clinical outcome. The median survival time is 9-12 months, with neither chemotherapeutic nor targeted agents showing substantial survival benefit in clinical trials in children with these tumors. We report the identification of recurrent activating mutations...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng.2925

Authors


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Funding agency for:
Bullock, A
Grant:
092809/Z/10/Z
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Funding agency for:
Bullock, A
Grant:
092809/Z/10/Z
Stavros Niarchos Foundation More from this funder
Abbie's Army More from this funder
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Funding agency for:
Bullock, A
Grant:
092809/Z/10/Z
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Publisher:
Nature Publishing Group
Journal:
Nature Genetics Journal website
Volume:
46
Pages:
457-461
Publication date:
2014-01-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Language:
English
Subjects:
UUID:
uuid:20c32fdc-5a01-4765-ab24-9731bc1834b2
Local pid:
ora:8389
Deposit date:
2014-05-08

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