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Thesis

Computational studies of protein helix kinks

Abstract:

Kinks are functionally important structural features found in the alpha-helices of many proteins, particularly membrane proteins. Structurally, they are points at which a helix abruptly changes direction. Previous kink definition and identification methods often disagree with one another.

Here I describe three novel methods to characterise kinks, which improve on existing approaches. First, Kink Finder, a computational method that consistently locates kinks and estimates the error i...

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Research group:
Oxford Protein Informatics Group
Oxford college:
Hertford College
Role:
Author
More by this author
Division:
MPLS
Department:
Statistics
Role:
Author

Contributors

Division:
MPLS
Department:
Statistics
Role:
Supervisor
Division:
MPLS
Department:
Statistics
Role:
Supervisor
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Funding agency for:
Wilman, H
Grant:
EP/G037280/1
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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