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Thesis

Computational studies of protein helix kinks

Abstract:

Kinks are functionally important structural features found in the alpha-helices of many proteins, particularly membrane proteins. Structurally, they are points at which a helix abruptly changes direction. Previous kink definition and identification methods often disagree with one another.

Here I describe three novel methods to characterise kinks, which improve on existing approaches. First, Kink Finder, a computational method that consistently locates kinks and estimates the error i...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
Oxford Protein Informatics Group
Oxford college:
Hertford College
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:21225f0e-efed-49c6-af27-5d3fe78fa731
Local pid:
ora:11726

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