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Thesis

Type 1 insulin-like growth factor receptor inhibition as treatment for urological cancer

Abstract:

The type 1 insulin-like growth factor receptor (IGF-1R) is a receptor tyrosine kinase that mediates diverse cellular functions including growth, differentiation, migration and apoptosis protection. IGF-1R signalling has been implicated in tumorigenesis in a variety of cancers, and IGF-1R inhibitory drugs are currently undergoing clinical evaluation. Previous work in our laboratory has shown IGF-1R over-expression in urological cancers at both the mRNA and protein level, thus making it a po...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
Christ Church
Role:
Author

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Role:
Supervisor
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Funding agency for:
Chitnis, M
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:21282ce9-ce6b-4d26-b262-a3fca6d9c9fc
Local pid:
ora:7255
Deposit date:
2013-09-04

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