Thesis
Single molecule studies of a voltage-gated potassium channel
- Abstract:
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This thesis aims to study the activation and deactivation mechanism of voltage-gated K+ channels (Kv), through fluorescence and electrical measurements. Transmembrane voltage changes are detected by the voltage sensor (helices S3b-S4) among Kv, a phenomenon which triggers a conformational change to open or close the pore. By attaching a fluorescent tag on helices S3b-S4, voltage sensor movement can be followed by fluorescence and pore opening or closure by...
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Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
Item Description
- Language:
- English
- Keywords:
- Subjects:
Terms of use
- Copyright holder:
- Lauriane Angué
- Copyright date:
- 2013
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