Thesis
Single molecule studies of a voltage-gated potassium channel
- Abstract:
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This thesis aims to study the activation and deactivation mechanism of voltage-gated K+ channels (Kv), through fluorescence and electrical measurements. Transmembrane voltage changes are detected by the voltage sensor (helices S3b-S4) among Kv, a phenomenon which triggers a conformational change to open or close the pore. By attaching a fluorescent tag on helices S3b-S4, voltage sensor movement can be followed by fluorescence and pore opening or closure by...
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Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:21cc3408-68c0-480c-a6f2-ab04edc0963d
- Deposit date:
- 2016-11-15
Terms of use
- Copyright holder:
- Angué, L
- Copyright date:
- 2013
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