Journal article

Asymmetric synthesis of (2S,3S)- and (2R,3S)-2,3-diaminobutanoic acids, non-protein amino-acid diastereomers found in a number of peptide antibiotics

Abstract:: (2S,3S)- and (2R,3S)-2,3-diaminobutanoic acids (DABA) are uncommon, naturally occurring amino acid diastereomers found as components of a number of peptide antibiotics. These 2,3-diamino acids have been synthesised by direct and indirect routes, with addition of a chiral lithium amide to tert-butyl crotonate as a key step.

Publication status:: Published

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APA Style

Burke, A., Davies, S., & Hedgecock, C. (1996). Asymmetric synthesis of (2S,3S)- and (2R,3S)-2,3-diaminobutanoic acids, non-protein amino-acid diastereomers found in a number of peptide antibiotics. SYNLETT, 1996(7), 621-and.

MLA Style

Burke, A., et al. “Asymmetric Synthesis of (2S,3S)- and (2R,3S)-2,3-Diaminobutanoic Acids, Non-Protein Amino-Acid Diastereomers Found in a Number of Peptide Antibiotics.” SYNLETT, vol. 1996, no. 7, 1996, pp. 621-and.

Chicago Style

Burke, A, S Davies, and C Hedgecock. 1996. “Asymmetric Synthesis of (2S,3S)- and (2R,3S)-2,3-Diaminobutanoic Acids, Non-Protein Amino-Acid Diastereomers Found in a Number of Peptide Antibiotics.” SYNLETT 1996 (7): 621-and.
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Publisher copy:: 10.1055/s-1996-5556

Authors

+ Burke, A More by this author

Role:: Author

+ Davies, S More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Hedgecock, C More by this author

Role:: Author

Journal:: SYNLETT More from this journal
Volume:: 1996
Issue:: 7
Pages:: 621-and
Publication date:: 1996-07-01
DOI:: 10.1055/s-1996-5556
EISSN:: 1437-2096
ISSN:: 0936-5214

Keywords:: Mitsunobu reaction

stereocontrol

2,3-diamino acids

conjugate addition

lithium amide
Pubs id:: pubs:110842
UUID:: uuid:220d7bc9-28ee-4273-a588-397ecc39cc21
Local pid:: pubs:110842
Source identifiers:: 110842
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 1996

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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