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Thesis

Regulation of anaphase in mammalian meiosis

Abstract:

Missegregation of chromosomes during meiosis leads to formation of aneuploid eggs. Estimates suggest that in humans, about 10-30% of fertilised eggs and one-third of all miscarriages are aneuploid. Accurate chromosome segregation depends on the coordination between stepwise cohesion resolution and attachments of homologous chromosomes through kinetochores to microtubules, emanating from opposite poles of the cell. The Spindle Assembly Checkpoint (SAC) monitors microtubule-kinetochore attac...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Kim Nasmyth, Bela Novak
Oxford college:
Brasenose College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:223a1f73-f881-415c-9e6d-70cc232a40ce
Deposit date:
2016-11-15

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