Characterization of lymphocytic choriomeningitis virus-binding protein(s): a candidate cellular receptor for the virus.

Journal article

The attachment of lymphocytic choriomeningitis virus (LCMV) to murine and primate cell lines was quantitated by a fluorescence-activated cell sorter assay in which binding of biotinylated virus was detected with streptavidin-fluorescein isothiocyanate. Cell lines that were readily infected by LCMV (e.g., MC57, Rin, BHK, Vero, and HeLa) bound virus in a dose-dependent manner, whereas no significant binding was observed to lymphocytic cell lines (e.g., RMA and WIL 2) that were not readily infec...

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Authors: Borrow, P; Oldstone, M

• Publication status: Published
• Journal: Journal of virology
• Volume: 66
• Issue: 12
• Pages: 7270-7281
• Publication date: 1992-12-01
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Cell Line; Phospholipases; Humans; Phosphoric Diester Hydrolases; Carrier Proteins; Antibodies; Phosphoinositide Phospholipase C; Neuraminidase; Phosphatidylinositol Diacylglycerol-Lyase; Receptors, Virus; Endopeptidases; Kinetics; Binding, Competitive; Membrane Proteins; Tunicamycin; Animals; Lymphocytic choriomeningitis virus; Glycoside Hydrolases; Mice