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Glutamatergic hypofunction in medication-free major depression: Secondary effects of affective diagnosis and relationship to peripheral glutaminase

Abstract:

Background There is uncertainty as to whether alterations in glutamatergic function in affective disorders differ between unipolar and bipolar disorders and between depressive and euthymic states. Additionally, there are currently no available blood-based markers of central glutamatergic function to support clinical diagnosis and aid brain based investigations. Methods In this study, we measured levels of glutamate in the dorsal anterior cingulate cortex in-vivo using 1H-Magnetic Resonance S...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jad.2018.02.059

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
ORCID:
0000-0003-4716-4662
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Affective Disorders Journal website
Volume:
234
Pages:
214-219
Publication date:
2018-02-27
Acceptance date:
2018-02-20
DOI:
EISSN:
1573-2517
ISSN:
0165-0327
Pmid:
29544167
Language:
English
Keywords:
Pubs id:
1165765
Local pid:
pubs:1165765
Deposit date:
2021-03-04

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