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Conference item

Ex vivo characterization of early secretory antigenic target 6–specific T cells at sites of active disease in pleural tuberculosis

Abstract:

Presence of early secretory antigenic target-6 (ESAT-6)—specific, interferon-γ—secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, ±6-fold), relative to their level in peripheral blood (P = .014), and displayed rapid effector function. Such cells were absent in 8 control patients with nontuberculous pleural disease. The recruitment of ESAT-6...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1086/426139

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
ORCID:
0000-0001-9827-9836
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Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
40
Issue:
1
Pages:
184-187
Host title:
Clinical Infectious Diseases
Publication date:
2005-01-01
Acceptance date:
2004-08-08
Event location:
United States
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pmid:
15614710
Source identifiers:
25278
Keywords:
Pubs id:
pubs:25278
UUID:
uuid:22c2c43b-7d24-4713-b99e-eb9202328e8d
Local pid:
pubs:25278
Deposit date:
2018-06-26

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