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Thesis

The cell surface organisation of the Notch-1 receptor

Abstract:

The Notch receptor family plays a key role in development and disease. In cancer, Notch can act either as an oncogene or as a tumour suppressor, and possibly as a cancer stem-cell factor. Whereas most research has focused on downstream signalling events, little is known about the cell surface organisation of Notch and its ligands. The extracellular part of Notch consists mainly of 36 epidermal growth factor-like domains (EGF-domains), many of which bind calcium. Studies have shown that tan...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Linacre College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
More from this funder
Funding agency for:
Weisshuhn, PC
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:2325997c-8cc7-4cf7-9ef2-03355c750ba6
Local pid:
ora:10545
Deposit date:
2015-03-12

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