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Centrosome function is critical during terminal erythroid differentiation

Abstract:

Red blood cells are produced by terminal erythroid differentiation, which involves the dramatic morphological transformation of erythroblasts into enucleated reticulocytes. Microtubules are important for enucleation, but it is not known if the centrosome, a key microtubule-organizing center, is required as well. Mice lacking the conserved centrosome component, CDK5RAP2, are likely to have defective erythroid differentiation because they develop macrocytic anemia. Here, we show that fetal live...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embj.2021108739

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-2441-8095
Cancer Research UK More from this funder
Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Article number:
e108739
Publication date:
2022-06-09
Acceptance date:
2022-05-25
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pmid:
35678476
Language:
English
Keywords:
Pubs id:
1264126
Local pid:
pubs:1264126
Deposit date:
2022-07-14

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